ACNE VULGARIS
Etiology & Pathophysiology Emotional    stress    influences    the    course    of    acne.    Cutaneous    neurogenic    factors    including    neuropeptides,    neuropeptide-degrading    enzymes    and neurotrophic   factors,   are   associated   with   inflammation   in   the   pathogenesis   of   acne.   An   increase   in   the   number   of   mast   cells    around   the   sebaceous glands   is   also   a   factor.   Substance   P    (SP)-immunoreactive   nerve   fibres   are   close   to   the   sebaceous   glands.   SP,   a   neuropeptide,   stimulates   lipogenesis    of the   sebaceous   glands,   which   may   be   followed   by   proliferation   of   Propionibacterium   acnes   (a   gram-positive   anaerobic   bacillus   rod).   This   paves   the   way for   inflammatory   reactions   via   the   mast   cells.   Although   Acne   vulgaris   is   not   life-threatening,   it   is   very   much   a   condition   with   serious   psychological   effects such   as   morbidity,   decreased   self-esteem,   depression,   and   social   withdrawal.   In   acne   vulgaris   abnormal   keratinisation ,   - hormonal   function ,   - bacterial   growth ,   and   i mmune   hypersensitivity   are   involved.   This   is   common   during   puberty   when   sebaceous   glands   are   particularly   active   in pilosebaceous   follicles   of   the   head   and   chest.   Over-production   of   sebum   is   stimulated   by   androgens   and   this   increased   production   is   associated   with plugged   follicle   pores,   which   may   become   inflamed   and   develop   into   inflammatory   acne.   This   inflammatory   acne   may   be   a   direct   response   to   the follicular inhabitant Propionibacterium acnes , which is a member of normal cutaneous flora. Stress   stimulates   the   corticotropin-releasing   hormone   (CRH)   system.   Receptors   of   corticotropin-releasing   factor   (CRF)   are   present   in   human   skin,   as   are mast cells. Stress-related crosstalk between mast cells, neurons and keratinocytes plays a significant role in all dermatological pathologies. CRH   is   capable   to   induce   lipid   synthesis,   steroidogenesis   and   interact   with   testosterone   and   growth   hormone.   An   overly-vigorous   immune   response   to Propionibacterium   acnes   (P.   acnes)   is   a   fundamental   problem   in   acne   vulgaris.   These   bacteria   secrete   polypeptides,   like   extracellular   enzymes,   such   as proteases,   hyaluronidases   and   neuroaminidases,   which   can   involve   epithelium   permeabilization   and   inflammatory   infiltration.   P.   acnes   produces   both chemotactic-   and   pro-inflammatory   cytokine   inducing   factors.   Early-infiltrated   lesions   consist   of   polymorphonuclear   cells.   These   cells   attract   T-helper cells   of   the   CD4   phenotype,   also   known   as   T4   cells.   Antibodies,   specifically-aimed   at   P.   acnes   antigenic   determinants,   are   IgG   and   IgA   immunoglobulins. Since   the   Toll   like   receptor   TLR2   plays   a   role   in   the   aetiology   of   acne,   its   stimulation   by   P.   acnes   gives   rise   to   the   production   of   Interleukin-8   (IL-8)-   and Interleukin-12 (IL-12) pro-inflammatory cytokines.
TARGETS Propionibacterium acnes bacteria Mast cells Corticotropin-releasing factor (CRF) Cytokines IL-8 and IL-12 Type1 5-α-reductase 5-Lipoxygenase Tyrosinase Reactive oxygen species (ROS)
COUNTERACTIONS Anti-bacterial Degranulation Inhibition Inhibition Inhibition Inhibition Inhibition Inhibition
God’s trial… ACNE VULGARIS
God’s garden grace…  Divine molecules locked up within His garden…molecules such as…
1 Corinthians 10:13 “No trial has overtaken you that is not faced by others. And God is faithful: He will not let you be tried beyond what you are able to bear, but with the trial will also provide a way out so that you may be able to endure it. “ – NET Bible
DISCLAIMER This   information   published   through   “God’s   Garden   Gifts”   website   is   provided   for   informational   purposes   only   and   any   action   on   your   part   in   response   to   the information   provided   on   this   website   is   at   the   reader's   own   discretion.   “God’s   Garden   Gifts”   makes   no   representations   or   warranties   with   respect   to   any information   shared   on   this   website   regarding   diagnosis,   treatment,   action,   or   application   of   any   kind.   Neither   “God’s   Garden   Gifts”,   nor   any   associated   person, is liable for any direct or indirect claim, loss or damage resulting from use of this website.
Cinnamaldehyde              Terpinen-4-ol               Geraniol               Benzyl acetate         Citronellol              1,8-Cineole               Trans-Anethole             Source: Mol-Instincts chemical          Source: Mol-Instincts chemical               Database (ChemEssen.com)                                                                               Database (ChemEssen.com)       …to name only 7 out of thousands of others. 
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ACNE VULGARIS
Etiology & Pathophysiology Emotional    stress    influences    the    course    of    acne.    Cutaneous neurogenic    factors    including    neuropeptides,    neuropeptide- degrading   enzymes   and   neurotrophic   factors,   are   associated with   inflammation   in   the   pathogenesis   of   acne.   An   increase   in the   number   of   mast   cells    around   the   sebaceous   glands   is   also a   factor.   Substance   P    (SP)-immunoreactive   nerve   fibres   are close   to   the   sebaceous   glands.   SP,   a   neuropeptide,   stimulates lipogenesis    of   the   sebaceous   glands,   which   may   be   followed by   proliferation   of   Propionibacterium   acnes   (a   gram-positive anaerobic   bacillus   rod).   This   paves   the   way   for   inflammatory reactions   via   the   mast   cells.   Although   Acne   vulgaris   is   not   life- threatening,     it     is     very     much     a     condition     with     serious psychological     effects     such     as     morbidity,     decreased     self- esteem,    depression,    and    social    withdrawal.    In    acne    vulgaris abnormal    keratinisation ,    - hormonal    function ,    - bacterial growth ,   and   i mmune   hypersensitivity   are   involved.   This   is common      during      puberty      when      sebaceous      glands      are particularly   active   in   pilosebaceous   follicles   of   the   head   and chest.   Over-production   of   sebum   is   stimulated   by   androgens and    this    increased    production    is    associated    with    plugged follicle   pores,   which   may   become   inflamed   and   develop   into inflammatory   acne.   This   inflammatory   acne   may   be   a   direct response     to     the     follicular     inhabitant     Propionibacterium acnes , which is a member of normal cutaneous flora. Stress    stimulates    the    corticotropin-releasing    hormone    (CRH) system.   Receptors   of   corticotropin-releasing   factor   (CRF)   are present    in    human    skin,    as    are    mast    cells.    Stress-related crosstalk   between   mast   cells,   neurons   and   keratinocytes   plays a significant role in all dermatological pathologies. CRH   is   capable   to   induce   lipid   synthesis,   steroidogenesis   and interact    with    testosterone    and    growth    hormone.    An    overly- vigorous    immune    response    to    Propionibacterium    acnes    (P. acnes)    is    a    fundamental    problem    in    acne    vulgaris.    These bacteria   secrete   polypeptides,   like   extracellular   enzymes,   such as   proteases,   hyaluronidases   and   neuroaminidases,   which   can involve      epithelium      permeabilization      and      inflammatory infiltration.    P.    acnes    produces    both    chemotactic-    and    pro- inflammatory      cytokine      inducing      factors.      Early-infiltrated lesions   consist   of   polymorphonuclear   cells.   These   cells   attract T-helper   cells   of   the   CD4   phenotype,   also   known   as   T4   cells. Antibodies,       specifically-aimed       at       P.       acnes       antigenic determinants,   are   IgG   and   IgA   immunoglobulins.   Since   the   Toll like   receptor   TLR2   plays   a   role   in   the   aetiology   of   acne,   its stimulation    by    P.    acnes    gives    rise    to    the    production    of Interleukin-8   (IL-8)-   and   Interleukin-12   (IL-12)   pro-inflammatory cytokines.
TARGETS Propionibacterium acnes bacteria Mast cells Corticotropin-releasing factor (CRF) Cytokines IL-8 and IL-12 Type1 5-α-reductase 5-Lipoxygenase Tyrosinase Reactive oxygen species (ROS)
COUNTERACTIONS Anti-bacterial Degranulation Inhibition Inhibition Inhibition Inhibition Inhibition Inhibition
1 Corinthians 10:13 “No trial has overtaken you that is not faced by others. And God is faithful: He will not let you be tried beyond what you are able to bear, but with the trial will also provide a way out so that you may be able to endure it. “ – NET Bible
God’s trial… ACNE VULGARIS
God’s garden grace…  Divine molecules locked up within His garden…molecules such as…
DISCLAIMER This     information     published     through     “God’s     Garden     Gifts” website   is   provided   for   informational   purposes   only   and   any action   on   your   part   in   response   to   the   information   provided   on this   website   is   at   the   reader's   own   discretion.   “God’s   Garden Gifts”   makes   no   representations   or   warranties   with   respect   to any   information   shared   on   this   website   regarding   diagnosis, treatment,   action,   or   application   of   any   kind.   Neither   “God’s Garden    Gifts”,    nor    any    associated    person,    is    liable    for    any direct   or   indirect   claim,   loss   or   damage   resulting   from   use   of this website.
Citronellol           1,8-Cineole            Trans-Anethole …to name only 7 out of thousands of others. 
Cinnamaldehyde   Terpinen-4-ol   Geraniol   Benzyl acetate                         Source: Mol-Instincts chemical                                Source: Mol-Instincts chemical    Database (ChemEssen.com)                                                 Database (ChemEssen.com)
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